Haring R, Ulrich J, Volzke H, Nauck M, Dorr M, Felix S, Wallaschofski H.
Men, compared to women, are at a higher risk of developing cardiovascular disease with a reduction in life expectancy 5 to 10 yrs. This observation may be related to low total testosterone levels suggesting that low total testosterone levels when men age may contribute to this phenomenon. This study looked at over 4000 German men and women aged 20 to 79 yrs old to investigate the risk of cardiovascular disease. What they found was very interesting in that men with low total testosterone levels had a higher risk of developing cardiovascular disease compared to men with higher total testosterone and women. This study demonstrates a difference in gender with men at higher risk than women and men with low total testosterone at higher risk than men with higher total testosterone levels. This study emphasizes the need for checking and monitoring men for possible low total testosterone, and raises the question of whether appropriate and adequate testosterone treatment may alter the cardiovascular risk in men with low total testosterone levels.